Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice

Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice

Inflammatory bowel diseases (IBD) are a growing health problem worldwide, severely affecting patients’ life qualities and life expectancies. Therapeutic options, which are rare and focus on symptoms associated with the disease, suffer from increasing numbers of patients refractory to the established...

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Bibliographic Details
Main Authors: Eva J. Wunschel, Bastian Schirmer, Roland Seifert, Detlef Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
TNBS-induced colitis
histamine
inflammation
receptor
GPCR
mouse models
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00642/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00642/full

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