Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells

Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells

In head and neck squamous cell carcinoma (HNSCC), tumors positive for human papillomavirus (HPV) represent a distinct biological entity with favorable prognosis. An enhanced radiation sensitivity of these tumors is evident in the clinic and on the cellular level when comparing HPV-positive and HPV-n...

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Bibliographic Details
Main Authors: Katharina Hintelmann, Thomas Berenz, Malte Kriegs, Sabrina Christiansen, Fruzsina Gatzemeier, Nina Struve, Cordula Petersen, Christian Betz, Kai Rothkamm, Agnes Oetting, Thorsten Rieckmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
human papillomavirus (HPV)
molecular targeting
radiotherapy
radiosensitization
PARP
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.683688/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.683688/full

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