Marine Natural Products with P-Glycoprotein Inhibitor Properties

• Main Authors: Dioxelis Lopez, Sergio Martinez-Luis
• Format: Article
• Language: English
• Published: MDPI AG 2014-01-01
• Series: Marine Drugs
• Subjects: P-glycoprotein; marine natural products; multidrug resistance
• Online Access: http://www.mdpi.com/1660-3397/12/1/525

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.