Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche

Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche

Summary: Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome of male mice at 2, 6, 18, and 22 months, we found that most of the genes that change significantly over...

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Bibliographic Details
Main Authors: Maria Apostolopoulou, Thomas R. Kiehl, Mark Winter, Edgar Cardenas De La Hoz, Nathan C. Boles, Christopher S. Bjornsson, Kristen L. Zuloaga, Susan K. Goderie, Yue Wang, Andrew R. Cohen, Sally Temple
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304605

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http://www.sciencedirect.com/science/article/pii/S2213671117304605

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