The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1

The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1

Abstract: Nuclear receptors are transcription factors that bind lipids, an event that induces a structural conformation of the receptor that favors interaction with transcriptional coactivators. The nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) binds the signaling phosphoinositides PI(4,5)P2...

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Bibliographic Details
Main Authors: Jamal M. Bryant, M. Merced Malabanan, Boden H. Vanderloop, Charles M. Nichols, Zeinab Haratipour, Katrina T. Poon, Stacy D. Sherrod, John A. McLean, Raymond D. Blind
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
nuclear PIP3
PtdIns(3,4,5)P3
PtdIns(4,5)P2
nuclear receptors
X-ray crystallography
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000638

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http://www.sciencedirect.com/science/article/pii/S0022227521000638

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