How to Tackle Underdeterminacy in Metabolic Flux Analysis? A Tutorial and Critical Review

Metabolic flux analysis is often (not to say almost always) faced with system underdeterminacy. Indeed, the linear algebraic system formed by the steady-state mass balance equations around the intracellular metabolites and the equality constraints related to the measurements of extracellular fluxes...

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Bibliographic Details
Main Authors: Philippe Bogaerts, Alain Vande Wouwer
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Processes
Subjects:
Online Access:https://www.mdpi.com/2227-9717/9/9/1577