Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses

Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses

Abstract Background Severe hypoglycemia induces brain edema by upregulating aquaporin-4 (AQP4) expression and by degrading tight junctions. Acute severe hypoglycemia induces a proinflammatory environment that may contribute to a disruption in the epithelial barrier by decreasing tight junction prote...

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Bibliographic Details
Main Authors: Fei Zhao, Jiangshan Deng, Xiaofeng Xu, Fengya Cao, Kaili Lu, Dawei Li, Xiaojuan Cheng, Xiuzhe Wang, Yuwu Zhao
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Hypoglycemia
AQP4
BBB
Tight junctions
PPAR-γ
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1203-8

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http://link.springer.com/article/10.1186/s12974-018-1203-8

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