HIV antigen incorporation within adenovirus hexon hypervariable 2 for a novel HIV vaccine approach.

HIV antigen incorporation within adenovirus hexon hypervariable 2 for a novel HIV vaccine approach.

Adenoviral (Ad) vectors have been used for a variety of vaccine applications including cancer and infectious diseases. Traditionally, Ad-based vaccines are designed to express antigens through transgene expression of a given antigen. However, in some cases these conventional Ad-based vaccines have h...

Full description

Bibliographic Details
Main Authors:	Qiana L Matthews, Aiman Fatima, Yizhe Tang, Brian A Perry, Yuko Tsuruta, Svetlana Komarova, Laura Timares, Chunxia Zhao, Natalia Makarova, Anton V Borovjagin, Phoebe L Stewart, Hongju Wu, Jerry L Blackwell, David T Curiel
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-07-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2910733?pdf=render

Similar Items

Derivation of a triple mosaic adenovirus for cancer gene therapy.
by: Yizhe Tang, et al.
Published: (2009-12-01)

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo.
by: Jiangtao Ma, et al.
Published: (2015-02-01)

Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon.
by: Ezazul Haque, et al.
Published: (2018-01-01)

CryoEM visualization of an adenovirus capsid-incorporated HIV antigen.
by: Justin W Flatt, et al.
Published: (2012-01-01)

Correction: Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon.
by: Ezazul Haque, et al.
Published: (2018-01-01)

Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses.
by: Joseph T Bruder, et al.
Published: (2012-01-01)

Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein
by: Xingui Tian, et al.
Published: (2015-10-01)

Correction: Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses
by: Joseph T. Bruder, et al.
Published: (2012-01-01)

Correction: Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses.
by: Joseph T. Bruder, et al.
Published: (2012-01-01)

P17-13. Hexon hypervariable regions 4–7 contain important Ad5-specific neutralizing antibody epitopes
by: Barouch DH, et al.
Published: (2009-10-01)

Human Adenovirus Serotype 3 Vector Packaged by a Rare Serotype 14 Hexon.
by: Xiaobo Su, et al.
Published: (2016-01-01)

Hexon-based scaffold for generation of diagnostic monoclonal antibodies against diverse adenovirus types
by: T. A. Timoshicheva, et al.
Published: (2019-05-01)

Evaluation of adenovirus capsid labeling versus transgene expression
by: Curiel David T, et al.
Published: (2010-01-01)

Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum.
by: Andrew W Harmon, et al.
Published: (2018-01-01)

Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo.
by: Jan-Michael Prill, et al.
Published: (2014-01-01)

Protection against enterovirus 71 with neutralizing epitope incorporation within adenovirus type 3 hexon.
by: Xingui Tian, et al.
Published: (2012-01-01)

Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene.
by: Elizabeth B Liu, et al.
Published: (2011-01-01)

Correction: Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon
by: Xingui Tian, et al.
Published: (2012-01-01)

Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro.
by: Johanna P Laakkonen, et al.
Published: (2012-01-01)

Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon
by: Julian Scherer, et al.
Published: (2011-08-01)

Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer.
by: Tanja Lucas, et al.
Published: (2015-01-01)

Correction: Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon.
by: Xingui Tian, et al.
Published: (2012-01-01)

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
by: Alexander T. Baker, et al.
Published: (2019-02-01)

Using multivalent adenoviral vectors for HIV vaccination.
by: Linlin Gu, et al.
Published: (2013-01-01)

Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.
by: Anitra L Farrow, et al.
Published: (2014-08-01)

Identification of Two Novel Linear Neutralizing Epitopes within the Hexon Protein of Canine Adenovirus Using Monoclonal Antibodies
by: Shujie Wang, et al.
Published: (2021-02-01)

Correction: Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer.
by: PLOS ONE Staff
Published: (2015-01-01)

Current progress in the development of a prophylactic vaccine for HIV-1
by: Lena J Gamble, et al.
Published: (2010-12-01)

Structure-based high-throughput epitope analysis of hexon proteins in B and C species human adenoviruses (HAdVs).
by: Xiao-Hui Yuan, et al.
Published: (2012-01-01)

Production and epitope mapping of monoclonal antibodies against the VP2 protein of canine parvovirus and the Hexon protein of canine adenovirus
by: Siao-Jyun Syu, et al.
Published: (2016)

Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction.
by: Stéphanie Corjon, et al.
Published: (2011-01-01)

Deep analysis of Loop L1 HVRs1-4 region of the hexon gene of adenovirus field strains isolated in Poland.
by: Jowita Samanta Niczyporuk
Published: (2018-01-01)

P19-06. The first hypervariable loop and HIV-1 neutralizing antibodies elicited by gp140 env immunogens
by: Stamatatos L, et al.
Published: (2009-10-01)

Genetic Incorporation of a Herpes Simplex Virus Type 1 Thymidine Kinase and Firefly Luciferase Fusion into the Adenovirus Protein IX for Functional Display on the Virion
by: Qiana L. Matthews, et al.
Published: (2006-10-01)

Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
by: Brennetta J. Crenshaw, et al.
Published: (2019-08-01)

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.
by: Di Yu, et al.
Published: (2013-01-01)

Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
by: Matthews Qiana L, et al.
Published: (2008-08-01)

A Novel Vaccine Approach for Chagas Disease Using Rare Adenovirus Serotype 48 Vectors
by: Anitra L. Farrow, et al.
Published: (2016-03-01)

Combination effect of adenovirus-mediated pro-apoptotic Bax gene transfer with cisplatin or paclitaxel treatment in ovarian cancer cell lines
by: Tsuruta, Yuko
Published: (2011)

Novel Adenovirus Vector-Based Vaccines for HIV
by: Letvin N, et al.
Published: (2005-12-01)

Cannot write session to /tmp/vufind_sessions/sess_41p8rv6jn1gipaocjbnpfeps1c