Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture. Previous studies reported that β-caryophyllene (BCP) mitigates cerebral ischemia-reperfusion (I/R) injury, but the underlying mechanism r...

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Bibliographic Details
Main Authors: Mei Yang, Yongjiu Lv, Xiaocui Tian, Jie Lou, Ruidi An, Qian Zhang, Minghang Li, Lu Xu, Zhi Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neuroscience
Subjects:
necroptosis
inflammation
β-caryophyllene
ischemia-reperfusion injury
oxygen-glucose deprivation and re-oxygenation
high-mobility group box 1
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00583/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00583/full

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