Hydrogen-Peroxide Synthesis and LDL-Uptake Controls Immunosuppressive Properties in Monocyte-Derived Dendritic Cells

Hydrogen-Peroxide Synthesis and LDL-Uptake Controls Immunosuppressive Properties in Monocyte-Derived Dendritic Cells

Background and Aims: Induction of myeloid-derived suppressor cells (MDSC) is a critical step in immune cell evasion by different cancer types, including liver cancer. In the liver, hepatic stromal cells orchestrate induction of MDSCs, employing a mechanism dependent on hydrogen peroxide (H<sub>...

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Bibliographic Details
Main Authors: Ann-Katrin Menzner, Tanja Rottmar, Simon Voelkl, Jacobus J. Bosch, Dimitrios Mougiakakos, Andreas Mackensen, Yazid J. Resheq
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
tolerogenic dendritic cells
catalase
hydrogen peroxide
reactive oxygen species
tumor immune escape
LDL-uptake
Online Access:https://www.mdpi.com/2072-6694/13/3/461

Internet

https://www.mdpi.com/2072-6694/13/3/461

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