The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1

The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1

Full functioning of the airway physical barrier depends on cellular integrity, which is coordinated by a series of tight junction (TJ) proteins. Due to airway spasm, edema, and mucus obstruction, positive end-expiratory alveolar pressure (also termed auto-PEEP) is a common pathophysiological phenome...

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Bibliographic Details
Main Authors: Jia Zhou, Xiang-dong Zhou, Rui Xu, Xian-zhi Du, Qi Li, Bin Li, Guo-yue Zhang, Ling-xiu Chen, Juliy M. Perelman, Victor P. Kolosov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
asthma
small airway epithelium
auto-PEEP
tight junction
piezo-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.637790/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.637790/full

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