Structural determinants of PINK1 topology and dual subcellular distribution

<p>Abstract</p> <p>Background</p> <p>PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization following mitochondrial processing remains unknown. Understand...

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Bibliographic Details
Main Authors: Kang Un, Lin William
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/11/90