Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy

Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy

Epidemiological data indicate that 20–40% of the patients with epilepsy are refractory to treatment with antiepileptic drugs (AEDs). The mechanisms underlying pharmacoresistance in epilepsy are unclear, but several plausible hypotheses have emerged, including loss of AED target sensitivity in the ep...

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Bibliographic Details
Main Authors: Kerstin Bethmann, Jean-Marc Fritschy, Claudia Brandt, Wolfgang Löscher
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Neurobiology of Disease
Subjects:
GABA
Phenobarbital
Pharmacoresistance
Hippocampus
Dentate gyrus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000053

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http://www.sciencedirect.com/science/article/pii/S0969996108000053

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