Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.

Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.

We used two-dimensional quantitative trait locus analysis to identify interacting genetic loci that contribute to the native airway constrictor hyperresponsiveness to methacholine that characterizes A/J mice, relative to C57BL/6J mice. We quantified airway responsiveness to intravenous methacholine...

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Bibliographic Details
Main Authors: Caroline M Ferreira, James L Chen, Jianrong Li, Kazuhiro Shimomura, Xinan Yang, Yves A Lussier, Lawrence H Pinto, Julian Solway
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3254621?pdf=render

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http://europepmc.org/articles/PMC3254621?pdf=render

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