The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation

Summary: CARMILs are large, multidomain, membrane-associated proteins that regulate actin assembly and Rho-family GTPases, but their role in inflammatory signaling is not defined. Tandem mass tag mass spectrometry indicated that, in fibroblasts, CARMIL1 associates with interleukin (IL)-1 signaling m...

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Bibliographic Details
Main Authors: Qin Wang, Karambir Notay, Gregory P. Downey, Christopher A. McCulloch
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
MMP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307610