The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

Staphylococcal species are a leading cause of bacterial drug-resistant infections and associated mortality. One strategy to combat bacterial drug resistance is to revisit compromised targets, and to circumvent resistance mechanisms using structure-assisted drug discovery. The folate pathway is an id...

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Bibliographic Details
Main Authors: Elizabeth C. Griffith, Miranda J. Wallace, Yinan Wu, Gyanendra Kumar, Stefan Gajewski, Pamela Jackson, Gregory A. Phelps, Zhong Zheng, Charles O. Rock, Richard E. Lee, Stephen W. White
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
infectious disease
antibiotics
drug discovery
fitness cost
kinetics
drug susceptibility
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01369/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01369/full

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