Microglia as target for anti-inflammatory approaches to prevent secondary brain injury after subarachnoid hemorrhage (SAH)

Abstract Background Microglia-driven cerebral spreading inflammation is a key contributor to secondary brain injury after SAH. Genetic depletion or deactivation of microglia has been shown to ameliorate neuronal cell death. Therefore, clinically feasible anti-inflammatory approaches counteracting mi...

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Bibliographic Details
Main Authors: Rebecca Heinz, Susan Brandenburg, Melina Nieminen-Kelhä, Irina Kremenetskaia, Philipp Boehm-Sturm, Peter Vajkoczy, Ulf C. Schneider
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:https://doi.org/10.1186/s12974-021-02085-3