MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics

Abstract Single cell experimental techniques reveal transcriptomic and epigenetic heterogeneity among cells, but how these are related is unclear. We present MATCHER, an approach for integrating multiple types of single cell measurements. MATCHER uses manifold alignment to infer single cell multi-om...

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Bibliographic Details
Main Authors: Joshua D. Welch, Alexander J. Hartemink, Jan F. Prins
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Genome Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13059-017-1269-0