Stability of the HSV-2 <i>US-6</i> Gene in the del II, del III, <i>CP77</i>, and <i>I8R</i>-<i>G1L</i> Sites in Modified Vaccinia Virus Ankara After Serial Passage of Recombinant Vectors in Cells

Stability of the HSV-2 <i>US-6</i> Gene in the del II, del III, <i>CP77</i>, and <i>I8R</i>-<i>G1L</i> Sites in Modified Vaccinia Virus Ankara After Serial Passage of Recombinant Vectors in Cells

The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others. Thus, transgene stability in MVA is important...

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Bibliographic Details
Main Authors: Vajini N. Atukorale, Jerry P. Weir, Clement A. Meseda
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
modified vaccinia virus ankara
vaccine stability
transgene
hsv-2
Online Access:https://www.mdpi.com/2076-393X/8/1/137

Internet

https://www.mdpi.com/2076-393X/8/1/137

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