AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

<p>Abstract</p> <p>Background</p> <p>Gossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enhances chemotherapy- and...

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Bibliographic Details
Main Authors: Rooswinkel Rogier, Bartelink Harry, van Blitterswijk Wim J, Lippman Marc E, Yang Dajun, Kuipers Gitta, Stoter Rianne, Zerp Shuraila F, Lafleur Vincent, Verheij Marcel
Format: Article
Language:English
Published: BMC 2009-10-01
Series:Radiation Oncology
Online Access:http://www.ro-journal.com/content/4/1/47

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http://www.ro-journal.com/content/4/1/47

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