Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited polymorphism (only 2 coding variants exist), and is not down-regulated by HIV-infecti...

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Bibliographic Details
Main Authors: Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2829052?pdf=render

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