Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures

Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures

Dysregulation of transcriptional pathways is observed in multiple forms of neurodevelopmental disorders (NDDs), such as intellectual disability (ID), epilepsy and autism spectrum disorder (ASD). We previously demonstrated that the NDD genes encoding lysine-specific demethylase 5C (<i>KDM5C<...

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Bibliographic Details
Main Authors: Loredana Poeta, Agnese Padula, Maria Brigida Lioi, Hans van Bokhoven, Maria Giuseppina Miano
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
neurodevelopmental disorders
X-chromosome
KDM5C
H3K4me3
disease mutations
NDD-related chromatinopathies
Online Access:https://www.mdpi.com/2073-4425/12/7/1088

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https://www.mdpi.com/2073-4425/12/7/1088

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