Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

Summary: There remains an unmet need for preclinical models to enable personalized therapy for ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids (PDOs) to predict clinical drug response and functional consequences of tumor heterogeneity. We included 36 whole-ge...

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Bibliographic Details
Main Authors: Chris Jenske de Witte, Jose Espejo Valle-Inclan, Nizar Hami, Kadi Lõhmussaar, Oded Kopper, Celien Philomena Henrieke Vreuls, Geertruida Nellie Jonges, Paul van Diest, Luan Nguyen, Hans Clevers, Wigard Pieter Kloosterman, Edwin Cuppen, Hugo Johannes Gerhardus Snippert, Ronald Peter Zweemer, Petronella Oda Witteveen, Ellen Stelloo
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
organoids
ovarian cancer
drug screening
chemotherapy
heterogeneity
WGS
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307427

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http://www.sciencedirect.com/science/article/pii/S2211124720307427

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