Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition

We report the implementation of our in silico/synthesis pipeline by targeting the glutathione-dependent enzyme mPGES-1, a valuable macromolecular target in both cancer therapy and inflammation therapy. Specifically, by using a virtual fragment screening approach of aromatic bromides, straightforward...

Full description

Bibliographic Details
Main Authors: Simone Di Micco, Stefania Terracciano, Dafne Ruggiero, Marianna Potenza, Maria C. Vaccaro, Katrin Fischer, Oliver Werz, Ines Bruno, Giuseppe Bifulco
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
fragment-based approach
Suzuki-Miyaura cross-coupling
mPGES-1 inhibitors
anti-inflammatory drugs
anticancer agents
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.676631/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.676631/full

Similar Items