The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

Colibactin-producing Escherichia coli strains are associated with cancerous and precancerous colorectal tissues and are suspected of promoting colorectal carcinogenesis. In this study, we describe a new interplay between the synthesis of the genotoxin colibactin and the polyamine spermidine. Polyami...

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Bibliographic Details
Main Authors: Camille V. Chagneau, Christophe Garcie, Nadège Bossuet-Greif, Sophie Tronnet, Alexander O. Brachmann, Jörn Piel, Jean-Philippe Nougayrède, Patricia Martin, Eric Oswald
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
escherichia coli
biosynthesis
colorectal cancer
genotoxic colibactin
polyamines
Online Access:https://doi.org/10.1128/mSphere.00414-19

Internet

https://doi.org/10.1128/mSphere.00414-19

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