Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer

Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer

An intricate network of molecular and cellular actors orchestrates the delicate balance between effector immune responses and immune tolerance. The pleiotropic cytokine tumor necrosis factor-alpha (TNF) proves as a pivotal protagonist promoting but also suppressing immune responses. These opposite a...

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Bibliographic Details
Main Authors: Harald Wajant, Andreas Beilhack
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
GVHD
graft vs. host disease
cancer
Tregs (regulatory T cells)
TNFR family costimulatory receptors
TNFR2 agonists
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02040/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02040/full

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