The design and construction of reference pangenome graphs with minigraph

Abstract The recent advances in sequencing technologies enable the assembly of individual genomes to the quality of the reference genome. How to integrate multiple genomes from the same species and make the integrated representation accessible to biologists remains an open challenge. Here, we propos...

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Bibliographic Details
Main Authors: Heng Li, Xiaowen Feng, Chong Chu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Genome Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13059-020-02168-z