Metabolic reprogramming by Zika virus provokes inflammation in human placenta

Metabolic reprogramming by Zika virus provokes inflammation in human placenta

Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imba...

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Main Authors: Qian Chen, Jordi Gouilly, Yann J. Ferrat, Ana Espino, Quentin Glaziou, Géraldine Cartron, Hicham El Costa, Reem Al-Daccak, Nabila Jabrane-Ferrat
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16754-z
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spelling doaj-70e1014b73ad480a95726b9d91fc3bd72021-06-13T11:19:30ZengNature Publishing GroupNature Communications2041-17232020-06-0111111610.1038/s41467-020-16754-zMetabolic reprogramming by Zika virus provokes inflammation in human placentaQian Chen0Jordi Gouilly1Yann J. Ferrat2Ana Espino3Quentin Glaziou4Géraldine Cartron5Hicham El Costa6Reem Al-Daccak7Nabila Jabrane-Ferrat8Center for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseCenter for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseCERAG Laboratory, University of Grenoble AlpesCenter for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseCenter for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseDepartment of Obstetrics and Gynecology, Paule de Viguier HospitalCenter for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseSaint-Louis Hospital, Inserm UMRS976, University of Paris DiderotCenter for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of ToulouseZika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.https://doi.org/10.1038/s41467-020-16754-z
collection DOAJ
language English
format Article
sources DOAJ
author Qian Chen
Jordi Gouilly
Yann J. Ferrat
Ana Espino
Quentin Glaziou
Géraldine Cartron
Hicham El Costa
Reem Al-Daccak
Nabila Jabrane-Ferrat
spellingShingle Qian Chen
Jordi Gouilly
Yann J. Ferrat
Ana Espino
Quentin Glaziou
Géraldine Cartron
Hicham El Costa
Reem Al-Daccak
Nabila Jabrane-Ferrat
Metabolic reprogramming by Zika virus provokes inflammation in human placenta
Nature Communications
author_facet Qian Chen
Jordi Gouilly
Yann J. Ferrat
Ana Espino
Quentin Glaziou
Géraldine Cartron
Hicham El Costa
Reem Al-Daccak
Nabila Jabrane-Ferrat
author_sort Qian Chen
title Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_short Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_full Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_fullStr Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_full_unstemmed Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_sort metabolic reprogramming by zika virus provokes inflammation in human placenta
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.
url https://doi.org/10.1038/s41467-020-16754-z
work_keys_str_mv AT qianchen metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT jordigouilly metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT yannjferrat metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT anaespino metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT quentinglaziou metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT geraldinecartron metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT hichamelcosta metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT reemaldaccak metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
AT nabilajabraneferrat metabolicreprogrammingbyzikavirusprovokesinflammationinhumanplacenta
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