p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich’s Ataxia

p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich’s Ataxia

Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich’s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-selective modes of DNA recognition are among the main...

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Bibliographic Details
Main Authors: Robert Helma, Pavla Bažantová, Marek Petr, Matej Adámik, Daniel Renčiuk, Vlastimil Tichý, Alena Pastuchová, Zuzana Soldánová, Petr Pečinka, Richard P. Bowater, Miroslav Fojta, Marie Brázdová
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
trinucleotide repeat
p53
non-B DNA
DNA hairpin
DNA–protein
frataxin
Online Access:https://www.mdpi.com/1420-3049/24/11/2078

Internet

https://www.mdpi.com/1420-3049/24/11/2078

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