In silico and in vitro analyses of the pathological relevance of the R258H mutation of hepatocyte nuclear factor 4α identified in maturity‐onset diabetes of the young type 1

In silico and in vitro analyses of the pathological relevance of the R258H mutation of hepatocyte nuclear factor 4α identified in maturity‐onset diabetes of the young type 1

Abstract Mutations of the hepatocyte nuclear factor 4α (HNF4α) gene give rise to maturity‐onset diabetes of the young type 1. Although many such mutations have been identified in affected individuals, part of these mutations has been characterized with regard to their pathological relevance. We here...

Full description

Bibliographic Details
Main Authors: Kenji Sugawara, Kazuhiro Nomura, Yuko Okada, Aki Sugano, Masaaki Matsumoto, Toru Takarada, Atsuko Takeuchi, Hiroyuki Awano, Yushi Hirota, Hisahide Nishio, Yutaka Takaoka, Wataru Ogawa
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Journal of Diabetes Investigation
Subjects:
Hepatocyte nuclear factor 4α
Insulin secretion
Maturity‐onset diabetes of the young type 1
Online Access:https://doi.org/10.1111/jdi.12960

Internet

https://doi.org/10.1111/jdi.12960

Similar Items