Apelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway

Apelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway

BackgroundAngiotensin II (Ang II) could promote the development of atrial fibrosis in atrial fibrillation (AF). Apelin can inhibit the occurrence of myocardial fibrosis. However, the effect of apelin on Ang II-induced atrial fibrosis and subsequent AF still remains unknown.ObjectiveIn the present st...

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Bibliographic Details
Main Authors: Wenkui Lv, Ling Zhang, Xinchun Cheng, Hongli Wang, Wen Qin, Xianhui Zhou, Baopeng Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
atrial fibrillation
apelin
angiotensin II
fibrosis
AF
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.583570/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.583570/full

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