Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine.

Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine.

Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine (DA) pathway is hypothesized to mediate these effects of PCP, the precise mechanisms by...

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Bibliographic Details
Main Authors: Yoko Hagino, Shinya Kasai, Wenhua Han, Hideko Yamamoto, Toshitaka Nabeshima, Masayoshi Mishina, Kazutaka Ikeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965660?pdf=render

Internet

http://europepmc.org/articles/PMC2965660?pdf=render

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