PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics

PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics

Abstract Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune PRS models using summary stat...

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Bibliographic Details
Main Authors: Zijie Zhao, Yanyao Yi, Jie Song, Yuchang Wu, Xiaoyuan Zhong, Yupei Lin, Timothy J. Hohman, Jason Fletcher, Qiongshi Lu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Biology
Subjects:
GWAS
Polygenic risk score
Model tuning
Summary statistics
Online Access:https://doi.org/10.1186/s13059-021-02479-9

Internet

https://doi.org/10.1186/s13059-021-02479-9

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