An incoherent feedforward loop facilitates adaptive tuning of gene expression

An incoherent feedforward loop facilitates adaptive tuning of gene expression

We studied adaptive evolution of gene expression using long-term experimental evolution of Saccharomyces cerevisiae in ammonium-limited chemostats. We found repeated selection for non-synonymous variation in the DNA binding domain of the transcriptional activator, GAT1, which functions with the repr...

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Bibliographic Details
Main Authors: Jungeui Hong, Nathan Brandt, Farah Abdul-Rahman, Ally Yang, Tim Hughes, David Gresham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
transcription factors
experimental evolution
gene expression
Online Access:https://elifesciences.org/articles/32323

Internet

https://elifesciences.org/articles/32323

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