Methylglyoxal Enhances Sodium Nitroprusside–Induced Relaxation in Rat Aorta

The concentration of methylglyoxal (MGO), a metabolite of glucose, increases in plasma of type II diabetic patients as well as in tissues of hypertensive rats. We have previously shown that MGO inhibited noradrenaline (NA)–induced smooth muscle contraction in rat aorta. However, the effect of MGO on...

Full description

Bibliographic Details
Main Authors: Masashi Mukohda, Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319310205