Factors affecting cell-free DNA fetal fraction: statistical analysis of 13,661 maternal plasmas for non-invasive prenatal screening

Factors affecting cell-free DNA fetal fraction: statistical analysis of 13,661 maternal plasmas for non-invasive prenatal screening

Abstract Background The identification of cell-free fetal DNA (cffDNA) facilitated non-invasive prenatal screening (NIPS) through analysis of cffDNA in maternal plasma. However, challenges regarding its clinical implementation become apparent. Factors affecting fetal fraction should be clarified to...

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Bibliographic Details
Main Authors: Yaping Hou, Jiexia Yang, Yiming Qi, Fangfang Guo, Haishan Peng, Dongmei Wang, Yixia Wang, Xiaohui Luo, Yi Li, Aihua Yin
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Human Genomics
Subjects:
Cell-free fetal DNA (cffDNA)
Fetal fraction
Gestational age
Maternal BMI
Maternal age
Online Access:https://doi.org/10.1186/s40246-019-0244-0

Internet

https://doi.org/10.1186/s40246-019-0244-0

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