Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation.

Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation.

RPE65 is an essential molecule in the retinoid-visual cycle, and RPE65 gene mutations cause the congenital human blindness known as Leber congenital amaurosis (LCA). Somatic gene therapy delivered to the retina of blind dogs with an RPE65 mutation dramatically restores retinal physiology and has spa...

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Bibliographic Details
Main Authors: Geoffrey K Aguirre, András M Komáromy, Artur V Cideciyan, David H Brainard, Tomas S Aleman, Alejandro J Roman, Brian B Avants, James C Gee, Marc Korczykowski, William W Hauswirth, Gregory M Acland, Gustavo D Aguirre, Samuel G Jacobson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1896221?pdf=render

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http://europepmc.org/articles/PMC1896221?pdf=render

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