Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

Abstract Background Chronic increases in the levels of the inflammatory cytokine interleukin-6 (IL-6) in serum and skeletal muscle are thought to contribute to the progression of muscular dystrophy. Dystrophin/utrophin double-knockout (dKO) mice develop a more severe and progressive muscular dystrop...

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Bibliographic Details
Main Authors: Eiji Wada, Jun Tanihata, Akira Iwamura, Shin’ichi Takeda, Yukiko K. Hayashi, Ryoichi Matsuda
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Skeletal Muscle
Subjects:
Interleukin-6
Duchenne muscular dystrophy
STAT3
Muscle regeneration
Fibrosis
Online Access:http://link.springer.com/article/10.1186/s13395-017-0140-z

Internet

http://link.springer.com/article/10.1186/s13395-017-0140-z

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