A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN

A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory phosphorylation sites that modulate function and sta...

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Bibliographic Details
Main Authors: Sebastian Rademacher, Nora T. Detering, Tobias Schüning, Robert Lindner, Pamela Santonicola, Inga-Maria Wefel, Janina Dehus, Lisa M. Walter, Hella Brinkmann, Agathe Niewienda, Katharina Janek, Miguel A. Varela, Melissa Bowerman, Elia Di Schiavi, Peter Claus
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
mass spectrometry
phosphorylation
PTEN
SMN
spinal muscular atrophy
Online Access:https://www.mdpi.com/2073-4409/9/11/2405

Internet

https://www.mdpi.com/2073-4409/9/11/2405

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