Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients

Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients

Rationale: Discordant alternans, a phenomenon in which the action potential duration (APDs) and/or intracellular calcium transient durations (CaDs) in different spatial regions of cardiac tissue are out of phase, present a dynamical instability for complex spatial dispersion that can be associated w...

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Bibliographic Details
Main Authors: Ilija Uzelac, Yanyan C. Ji, Daniel Hornung, Johannes Schröder-Scheteling, Stefan Luther, Richard A. Gray, Elizabeth M. Cherry, Flavio H. Fenton
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
discordant alternans
calcium dynamics
voltage-calcium coupling
arrhythmia
optical mapping
long QT syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00819/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00819/full

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