Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis, Characterization, and in Vitro Release Study

Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis, Characterization, and in Vitro Release Study

Novel and promising macromolecular conjugates of the α1-adrenergic blocker prazosin were directly synthesized by covalent incorporation of the drug to matrices composed of biodegradable polymers and α-amino acids for the development of a polymeric implantable drug delivery carrier. The cyto- and gen...

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Bibliographic Details
Main Authors: Ewa Oledzka, Anna Sawicka, Marcin Sobczak, Grzegorz Nalecz-Jawecki, Agata Skrzypczak, Waclaw Kolodziejski
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
controlled release/delivery
macromolecular drug delivery
biodegradable polymers
polymeric drug delivery system
prazosin
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/20/8/14533

Internet

http://www.mdpi.com/1420-3049/20/8/14533

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