A mechanistic view of mitochondrial death decision pores

A mechanistic view of mitochondrial death decision pores

Mitochondria increase their outer and inner membrane permeability to solutes, protons and metabolites in response to a variety of extrinsic and intrinsic signaling events. The maintenance of cellular and intraorganelle ionic homeostasis, particularly for Ca2+, can determine cell survival or death. M...

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Bibliographic Details
Main Authors: J.E. Belizário, J. Alves, J.M. Occhiucci, M. Garay-Malpartida, A. Sesso
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2007-08-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Mitochondrial outer membrane permeabilization
Permeability transition pore
Cytochrome c
Reactive oxygen species
Caspases
BCL-2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800001

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800001

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