Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer

Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer

Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous histotype. Further, while dysregulation of the folate-dependent 1-carbon cycle has been implicated in tumorogenesis, little is known relative to the potential mechanism of act...

Full description

Bibliographic Details
Main Authors: Sergei I. Agoulnik, Zoltan Dezso, Bryan E. Hoffman, Natalie C. Twine, Stephen M. Jackson, Daniel J. O'Shannessy, Elizabeth B. Somers
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
folate receptor alpha
FRA
ovarian cancer
fallopian tube
1-carbon metabolism
reduced folate carrier
methylation
Online Access:http://www.mdpi.com/1422-0067/14/7/13687

Internet

http://www.mdpi.com/1422-0067/14/7/13687

Similar Items