Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs

Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs

Abstract Background The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterine hyperglycemia per se has not been assessed alone. A number of studies...

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Bibliographic Details
Main Authors: Jun Ren, Yi Cheng, Zhen-Hua Ming, Xin-Yan Dong, Yu-Zhong Zhou, Guo-Lian Ding, Hai-Yan Pang, Tanzil Ur Rahman, Rubab Akbar, He-Feng Huang, Jian-Zhong Sheng
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Intrauterine hyperglycemia
Primordial germ cells
Reduced representation bisulfite sequencing
Epigenetic inheritance
Online Access:http://link.springer.com/article/10.1186/s13072-018-0192-2

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http://link.springer.com/article/10.1186/s13072-018-0192-2

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