Nanoparticle-mediated local delivery of an antisense TGF-β1 construct inhibits intimal hyperplasia in autogenous vein grafts in rats.

Nanoparticle-mediated local delivery of an antisense TGF-β1 construct inhibits intimal hyperplasia in autogenous vein grafts in rats.

Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening.In the present study, we performed immunohistochemistry, RT-PCR, and...

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Bibliographic Details
Main Authors: Da-Xin Sun, Zhen Liu, Xiao-Dong Tan, Dong-Xu Cui, Bao-Sheng Wang, Xian-Wei Dai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3408488?pdf=render

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http://europepmc.org/articles/PMC3408488?pdf=render

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