Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression

Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression

Abstract Background Neural tube defects (NTDs) are common birth defects involving the central nervous system. Recent studies on the etiology of human NTDs have raised the possibility that epigenetic regulation could be involved in determining susceptibility to them. Results Here, we show that the H2...

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Bibliographic Details
Main Authors: Ye Lin, Juan Yu, Jianxin Wu, Shan Wang, Ting Zhang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Epigenetics & Chromatin
Subjects:
Neural tube defect
Histone ubiquitination
RA
CUL4B
RORγ
HOX genes
Online Access:http://link.springer.com/article/10.1186/s13072-019-0268-7

Internet

http://link.springer.com/article/10.1186/s13072-019-0268-7

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