Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

DNA double-strand breaks (DSBs) are repaired by either the homology-directed repair (HDR) or the non-homologous end-joining (NHEJ) pathway. RIF1 (RAP1-interacting factor homolog) was recently shown to stimulate NHEJ through an interaction with 53BP1 (p53-binding protein 1) phosphorylated at S/TQ sit...

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Bibliographic Details
Main Authors: Shin-Ya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
DNA double-strand breaks
BRCA1
RIF1
53BP1
SCAI
NHEJ
HDR
alternative NHEJ
resection-dependent NHEJ
genomic instability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308872

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717308872

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