Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

Abstract BackgroundPsoriasis is a cytokine‐mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild psoriasis. To develop more targeted therapies, interf...

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Bibliographic Details
Main Authors: William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Format: Article
Language:English
Published: Wiley 2015-12-01
Series:Clinical and Translational Medicine
Subjects:
AP‐1
Decoy oligonucleotide
IRF
Motif
NF‐kappaB
ODN
Online Access:https://doi.org/10.1186/s40169-015-0054-5

Internet

https://doi.org/10.1186/s40169-015-0054-5

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