IL-7 During Antigenic Stimulation Using Allogeneic Dendritic Cells Promotes Expansion of CD45RA-CD62L+CD4+ Invariant NKT Cells With Th-2 Biased Cytokine Production Profile

IL-7 During Antigenic Stimulation Using Allogeneic Dendritic Cells Promotes Expansion of CD45RA-CD62L+CD4+ Invariant NKT Cells With Th-2 Biased Cytokine Production Profile

Invariant natural killer T (iNKT) cells are innate-like T lymphocytes cells that recognize glycolipid antigens associated with CD1d, non-classical antigen presenting proteins. They can drive either pro-inflammatory (Th-1) or anti-inflammatory (Th-2) immune microenvironment through the production of...

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Bibliographic Details
Main Authors: Abel Trujillo-Ocampo, Hyun-Woo Cho, Michael Clowers, Sumedha Pareek, Wilfredo Ruiz-Vazquez, Sung-Eun Lee, Jin S. Im
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
ex vivo expansion
human iNKT cells
Th2 polarization of expanded iNKT cells
IL-2
IL-7
IL-15
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.567406/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.567406/full

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