Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of <i>KEAP1</i> and <i>NFE2L2</i> genes an...

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Main Authors: Angelo Sparaneo, Federico Pio Fabrizio, Annamaria la Torre, Paolo Graziano, Massimo Di Maio, Andrea Fontana, Michele Bisceglia, Antonio Rossi, Stefano Pizzolitto, Giovanna De Maglio, Antonio Tancredi, Franco Grimaldi, Teresa Balsamo, Flavia Centra, Maria Carmina Manzorra, Domenico Trombetta, Angela Pantalone, Antonio Bonfitto, Evaristo Maiello, Vito Michele Fazio, Lucia Anna Muscarella
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
Lung Carcinoid
KEAP1
NRF2
methylation
mutation
outcome
Online Access:https://www.mdpi.com/1422-0067/20/10/2531

Internet

https://www.mdpi.com/1422-0067/20/10/2531

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